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Article

Effects of localized HLA class II beta chain polymorphism on binding of antigenic peptide and stimulation of T cells.

Human immunology - 1 Mar 1992

Newton-Nash D K, Eckels D D

Abstract excerpt

The relationship between HLA-DR1 polymorphism and recognition of antigen by T cells was investigated. Two allelic variants of HLA-DR1, which differ by amino acid substitution at positions 85 and 86 of the beta chain, were characterized for the effect of substitution on recognition of foreign antigen by DR1-restricted T cells. Substitution of alanine and valine for valine and glycine residues at positions 85 and...

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Identifiers

PMID: 1618659
DOI: 10.1016/0198-8859(92)90074-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of localized HLA class II beta chain polymorphism on binding of antigenic peptide and stimulation of T cells.PMID 1618659Read ↗

Differential effect of polymorphism at HLA-DR1 beta-chain positions 85 and 86 on binding and recognition of DR1-restricted antigenic peptides.Semantic proximity Read ↗

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.Semantic proximity Read ↗

Role of the polymorphic residues in HLA-DR molecules in allele-specific binding of peptide ligands.Semantic proximity Read ↗

Effect of natural polymorphism at residue 86 of the HLA-DR beta chain on peptide binding.Semantic proximity Read ↗

Individual effects of the DR11-variable beta-chain residues 67, 71, and 86 upon DR(alpha,beta 1*1101)-restricted, peptide-specific T cell proliferation.Semantic proximity Read ↗

The specificity of alloreactive T cells is determined by MHC polymorphisms which contact the T cell receptor and which influence peptide binding.Semantic proximity Read ↗

An HLA-DRB alpha-helix motif shared by DR11 and DR8 alleles is implicated in the pluriallelic restriction of peptide-specific T-cell lines.Semantic proximity Read ↗

Sequence polymorphism of HLA DR beta 1 alleles relating to T-cell-recognized determinants.Semantic proximity Read ↗

HLA-DQ polymorphisms are highly selective for peptide binding interactions.Semantic proximity Read ↗

Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR.Semantic proximity Read ↗

The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86.Semantic proximity Read ↗

Polymorphism at beta 85 and not beta 86 of HLA-DR1 is predominantly responsible for restricting the nature of the anchor side chain: implication for concerted effects of class II MHC polymorphism.Semantic proximity Read ↗

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