Effects of localized HLA class II beta chain polymorphism on binding of antigenic peptide and stimulation of T cells.

doi:10.1016/0198-8859(92)90074-w

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Article

Effects of localized HLA class II beta chain polymorphism on binding of antigenic peptide and stimulation of T cells.

Human immunology - 1 Mar 1992

Newton-Nash D K, Eckels D D

Abstract excerpt

The relationship between HLA-DR1 polymorphism and recognition of antigen by T cells was investigated. Two allelic variants of HLA-DR1, which differ by amino acid substitution at positions 85 and 86 of the beta chain, were characterized for the effect of substitution on recognition of foreign anti...

Topics

Alleles
Amino Acid Sequence
Antigens
Cell Line
HLA-DR1 Antigen
Humans
Lymphocyte Activation
Molecular Sequence Data
Polymorphism, Genetic
T-Lymphocytes

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