Article
Mutations in MHC class II dimer of dimers contact residues: effects on antigen presentation.
International immunology - 1 Aug 1998
Nydam T, Wade T K, Yadati S, Gabriel J L, Barisas B G, Wade W F
Abstract excerpt
The recent solutions of the MHC class II crystal structure reveal dimerization of the alphabeta heterodimers. These dimer of dimers structures may also exist either on resting cells or after engagement by TCR, and may be involved in B cell signaling and up-regulation of co-stimulatory molecules s...
Topics
- Antibodies, Monoclonal
- Antigen Presentation
- Antigen-Presenting Cells
- B-Lymphocytes
- B7-1 Antigen
- CD40 Antigens
- Clone Cells
- Cyclic AMP
- Dimerization
- Flow Cytometry
- HLA-DR1 Antigen
- Histocompatibility Antigens Class II
- Intercellular Adhesion Molecule-1
- Membrane Proteins
- Models, Molecular
- Mutation
- Phenotype
- Polymerase Chain Reaction