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Article

Mutations in MHC class II dimer of dimers contact residues: effects on antigen presentation.

International immunology - 1 Aug 1998

Nydam T, Wade T K, Yadati S, Gabriel J L, Barisas B G, Wade W F

Abstract excerpt

The recent solutions of the MHC class II crystal structure reveal dimerization of the alphabeta heterodimers. These dimer of dimers structures may also exist either on resting cells or after engagement by TCR, and may be involved in B cell signaling and up-regulation of co-stimulatory molecules such as B7 which facilitate T cell activation. By combining crystallographic data on HLA-DR1 with the sequence of murine...

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Source

Identifiers

PMID: 9723711
DOI: 10.1093/intimm/10.8.1237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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