Article
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.
The Journal of experimental medicine - 1 Nov 1995
Hosken N A, Shibuya K, Heath A W, Murphy K M, O'Garra A
Abstract excerpt
The dose of foreign antigen can influence whether a cell-mediated or humoral class of immune response is elicited, and this may be largely accounted for by the development of CD4+ T helper cells (Th) producing distinct sets of cytokines. The ability of antigen dose to direct the development of a Th1 or Th2 phenotype from naive CD4+ T cells, however, has not been demonstrated. In this report, we show that the...
Topics
- Animals
- Antigen Presentation
- B-Lymphocytes
- Dendritic Cells
- Dose-Response Relationship, Immunologic
- Female
- Histocompatibility Antigens Class II
- Immunologic Memory
- Interferon-gamma
- Interleukin-4