Article
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.
Cancer research - 1 Dec 1995
Parsons R, Myeroff L L, Liu B, Willson J K, Markowitz S D, Kinzler K W, Vogelstein B
Abstract excerpt
The TGF beta type II receptor (RII) was found to be mutated within a polyadenine tract in 100 of 111 (90%) colorectal cancers with microsatellite instability. Other polyadenine tracts of similar length were mutated in these samples but not as frequently as RII. In most cases, the polyadenine trac...
Topics
- Animals
- Base Sequence
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA, Neoplasm
- DNA, Satellite
- Humans
- Mice
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta
- Sequence Analysis, DNA
- Tumor Cells, Cultured