Article
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.
Cancer research - 1 Dec 1995
Parsons R, Myeroff L L, Liu B, Willson J K, Markowitz S D, Kinzler K W, Vogelstein B
Abstract excerpt
The TGF beta type II receptor (RII) was found to be mutated within a polyadenine tract in 100 of 111 (90%) colorectal cancers with microsatellite instability. Other polyadenine tracts of similar length were mutated in these samples but not as frequently as RII. In most cases, the polyadenine tract mutations affected both alleles of RII, and in four tumors heterozygous for the polyadenine mutations, three had...
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