Article
Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas.
Cancer research - 15 Jul 1998
Grady W M, Rajput A, Myeroff L, Liu D F, Kwon K, Willis J, Markowitz S
Abstract excerpt
The transforming growth factor-beta (TGF-beta) type II receptor (RII) is a colon cancer suppressor gene that is inactivated by mutation in 90% of human colon cancers arising via the microsatellite instability (MSI) pathway of carcinogenesis. To determine the pathophysiological consequence of RII...
Topics
- Adenoma
- Adult
- Aged
- Aged, 80 and over
- Carcinoma
- Cell Transformation, Neoplastic
- Colonic Neoplasms
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta