Article
A transforming growth factor beta 1 receptor type II mutation in ulcerative colitis-associated neoplasms.
Gastroenterology - 1 Jan 1997
Souza R F, Lei J, Yin J, Appel R, Zou T T, Zhou X, Wang S, Rhyu M G, Cymes K, Chan O, Park W S, Krasna M J, Greenwald B D, Cottrell J, Abraham J M, Simms L, Leggett B, Young J, Harpaz N, Meltzer S J
Abstract excerpt
BACKGROUND & AIMS: Numerous gastrointestinal tumors, notably sporadic and ulcerative colitis (UC)-associated colorectal carcinomas and dysplasias, gastric cancers, and esophageal carcinomas, manifest microsatellite instability. Recently, a transforming growth factor beta 1 type II receptor (TGF-beta 1RII) mutation in a coding microsatellite was described in colorectal carcinomas showing instability. One hundred...
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