Article
Genetic instability and mutation of the TGF-beta-receptor-II gene in ampullary carcinomas.
International journal of cancer - 4 May 1998
Imai Y, Tsurutani N, Oda H, Inoue T, Ishikawa T
Abstract excerpt
Ampullary carcinomas are relatively rare cancers of which very little is known in terms of carcinogenetic mechanisms at the molecular level. Genetic instability caused by mutations of mismatch-repair genes has been demonstrated to be responsible for hereditary non-polyposis colorectal cancers and a sub-set of sporadic colorectal cancers. In some of those tumors showing genetic instability, the...
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