Article
Alterations of transforming growth factor-beta 1 receptor type II occur in ulcerative colitis-associated carcinomas, sporadic colorectal neoplasms, and esophageal carcinomas, but not in gastric neoplasms.
Human cell - 1 Sept 1996
Souza R F, Garrigue-Antar L, Lei J, Yin J, Appel R, Vellucci V F, Zou T T, Zhou X, Wang S, Rhyu M G, Cymes K, Chan O, Park W S, Krasna M J, Greenwald B D, Cottrell J, Abraham J M, Simms L, Leggett B, Young J, Harpaz N, Reiss M, Meltzer S J
Abstract excerpt
BACKGROUND & AIMS: Gastric cancers, sporadic colorectal cancers, and ulcerative colitis (UC)-associated colorectal carcinomas and dysplasias manifest microsatellite instability (MI); however, esophageal carcinomas rarely exhibit MI. Recently, a transforming growth factor-beta 1 type II receptor (TGF-beta 1RII) mutation in a coding microsatellite was described in primary colorectal carcinomas demonstrating MI. No...
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