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Article

Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors.

Genes & development - 15 Mar 2002

Katan-Khaykovich Yael, Struhl Kevin

Abstract excerpt

DNA-binding activators and repressors recruit histone acetylases and deacetylases to promoters, thereby generating localized domains of modified histones that influence transcriptional activity. At the end of a transcriptional response, alterations in histone acetylation status are reversed, but the dynamics of this process are poorly understood. Here, we recruit histone deacetylases and acetylases to a...

Topics

Acetylation
Alleles
Chromatin
DNA
Dose-Response Relationship, Drug
Gene Expression Regulation
Histone Deacetylases
Histones
Kinetics
Nucleosomes
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precipitin Tests

Promoter Regions, Genetic

Time Factors

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 11914279
DOI: 10.1101/gad.967302
PMCID: PMC155357

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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