Article
Core promoter-dependent TFIIB conformation and a role for TFIIB conformation in transcription start site selection.
Molecular and cellular biology - 1 Oct 2002
Fairley Jennifer A, Evans Rachel, Hawkes Nicola A, Roberts Stefan G E
Abstract excerpt
The general transcription factor TFIIB plays a central role in the selection of the transcription initiation site. The mechanisms involved are not clear, however. In this study, we analyze core promoter features that are responsible for the susceptibility to mutations in TFIIB and cause a shift in the transcription start site. We show that TFIIB can modulate both the 5' and 3' parameters of transcription start...
Topics
- 3' Flanking Region
- 5' Flanking Region
- Base Sequence
- Humans
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Protein Binding
- Protein Conformation
- Structure-Activity Relationship