Loss of heterozygosity on chromosome 13q12-q14, BRCA-2 mutations and lack of BRCA-2 promoter hypermethylation in sporadic epithelial ovarian tumors.

doi:10.1002/1097-0142(20010815)92:4<787::aid-cncr1384>3.0.co;2-4

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Article

Loss of heterozygosity on chromosome 13q12-q14, BRCA-2 mutations and lack of BRCA-2 promoter hypermethylation in sporadic epithelial ovarian tumors.

Cancer - 15 Aug 2001

Gras E, Cortes J, Diez O, Alonso C, Matias-Guiu X, Baiget M, Prat J

Abstract excerpt

BACKGROUND: BRCA-1 and BRCA-2 are tumor suppressor genes in familial breast-ovarian carcinoma syndrome. BRCA-1 is also a tumor suppressor gene in sporadic ovarian carcinomas. However, the role of BRCA-2 in sporadic ovarian tumors remains unclear. METHODS: DNA from 52 patients with clinically apparent sporadic ovarian tumors was extracted from blood and from fresh-frozen tumor tissue and normal tissue (10 benign,...

Topics

BRCA2 Protein
Carcinoma
Chromosomes, Human, Pair 13
DNA Methylation
DNA, Neoplasm
Female
Genes, Tumor Suppressor
Humans
Loss of Heterozygosity
Microsatellite Repeats
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Proteins

Ovarian Neoplasms

Pedigree

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Sequence Analysis, DNA

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 11550149
DOI: 10.1002/1097-0142(20010815)92:4<787::aid-cncr1384>3.0.co;2-4

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