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Article

Genetic alterations in ?normal? luminal and myoepithelial cells of the breast

1 Dec 1999

Abstract excerpt

Chromosomal loci exhibiting loss of heterozygosity (LOH) at high frequency in invasive breast cancer have been investigated in 'normal' breast tissue from patients with carcinoma and from reduction mammoplasty specimens. Duct-lobular units dissected from paraffin-embedded tissues and 485 'normal' luminal and myoepithelial cell clones were studied. Overall, LOH was found in normal cells in 5/10 breast cancer cases...

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PMID: 10629549
DOI: 10.1002/(sici)1096-9896(199912)189:4<496::aid-path485>3.0.co;2-d

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Source receipt: pubmed, retrieved 7 Sept 2026.

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