Allelic imbalance on chromosome 13q: evidence for the involvement of BRCA2 and RB1 in sporadic breast cancer.

Article

Allelic imbalance on chromosome 13q: evidence for the involvement of BRCA2 and RB1 in sporadic breast cancer.

Cancer research - 1 May 1996

Hamann U, Herbold C, Costa S, Solomayer E F, Kaufmann M, Bastert G, Ulmer H U, Frenzel H, Komitowski D

Abstract excerpt

Recently, the breast cancer susceptibility gene BRCA2 has been identified in chromosome 13q, a region that also contains the retinoblastoma gene RB1. To elucidate a possible role of BRCA2 and RB1 in sporadic breast tumorigenesis, allelic imbalance (AI) at 13q loci was examined in 78 primary spora...

Topics

Alleles
BRCA2 Protein
Breast Neoplasms
Chromosome Mapping
Chromosomes, Human, Pair 13
Genes, Retinoblastoma
Genetic Markers
Humans
Neoplasm Proteins
Transcription Factors

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