Article
Somatic mitochondrial mutation in gastric cancer.
The American journal of pathology - 1 Oct 1995
Burgart L J, Zheng J, Shu Q, Strickler J G, Shibata D
Abstract excerpt
Likely hot spots for mutations are mitochondrial sequences as there is less repair and more damage by carcinogens compared with nuclear sequences. A somatic 50-bp mitochondrial D-loop deletion was detected in four gastric adenocarcinomas. The deletion included the CSB2 region and was flanked by 9-bp direct repeats. The deletion was more frequent in adenocarcinomas arising from the gastroesophageal junction (4/32,...
Topics
- Adenocarcinoma
- Base Sequence
- Gene Deletion
- Humans
- Mitochondria
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Polymorphism, Single-Stranded Conformational
- Stomach Neoplasms