Article
Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression.
World journal of gastroenterology - 14 Apr 2014
Lee Hsin-Chen, Huang Kuo-Hung, Yeh Tien-Shun, Chi Chin-Wen
Abstract excerpt
Energy metabolism reprogramming was recently identified as one of the cancer hallmarks. One of the underlying mechanisms of energy metabolism reprogramming is mitochondrial dysfunction caused by mutations in nuclear genes or mitochondrial DNA (mtDNA). In the past decades, several types of somatic mtDNA alterations have been identified in gastric cancer. However, the role of these mtDNA alterations in gastric...
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