Article
Somatic mutations of mitochondrial DNA in digestive tract cancers.
Journal of gastroenterology and hepatology - 1 Nov 2005
Kose Kazuhiro, Hiyama Toru, Tanaka Shinji, Yoshihara Masaharu, Yasui Wataru, Chayama Kazuaki
Abstract excerpt
BACKGROUND: Somatic mutations of mitochondrial DNA (mtDNA) have been reported to play an important role in the carcinogenesis of several human cancers. However, there are few reports on mtDNA mutations in digestive tract cancers, including esophageal, gastric and colorectal cancers. The present study examined somatic mtDNA mutations in these cancers. METHODS: Samples of 82 esophageal cancers, 96 gastric cancers...
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