Article
Frequent somatic mutations of mitochondrial DNA in esophageal squamous cell carcinoma.
International journal of cancer - 10 Jan 2004
Kumimoto Hiroshi, Yamane Yoshihiro, Nishimoto Yoshio, Fukami Hiroko, Shinoda Masayuki, Hatooka Shunzo, Ishizaki Kanji
Abstract excerpt
Recent studies of various cancers, such as those of the breast, head and neck, bladder and lung, reported that 46-64% of somatic mutations in the D-loop region of mitochondrial DNA (mtDNA) are observed. However, in esophageal cancer, only a low rate (5%) of somatic mutations has so far been reported in one article (Hibi, K. et al., Int J Cancer 2001;92:319-321). Thus, to confirm this we analyzed the somatic...
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