Article
Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny.
Mutation research - 10 May 2011
Bi Rui, Li Wen-Liang, Chen Ming-Qing, Zhu Zhu, Yao Yong-Gang
Abstract excerpt
Mitochondrial DNA (mtDNA) somatic mutations have been identified in nearly all kinds of cancer during the past decade. Normally one need to determine the complete mtDNA sequences from both cancerous and normal tissues of the same patient to score the somatic mutation in cancer. In this study, we intended to explore a strategy to quickly identify somatic mutations in the entire mtDNA genome based on its phylogeny....
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