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Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer.

Biochimica et biophysica acta - 1 Mar 2010

Hung Wen-Yi, Wu Chew-Wun, Yin Pen-Hui, Chang Chun-Ju, Li Anna Fen-Yau, Chi Chin-Wen, Wei Yau-Huei, Lee Hsin-Chen

Abstract excerpt

BACKGROUND: Somatic mutation in mitochondrial DNA (mtDNA) has been proposed to contribute to initiation and progression of human cancer. In our previous study, high frequency of somatic mutations was found in the D-loop region of mtDNA of gastric cancers. However, it is unclear whether somatic mutations occur in the coding region of mtDNA of gastric cancers. METHODS: Using DNA sequencing, we studied 31 gastric...

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PMID: 19527772
DOI: 10.1016/j.bbagen.2009.06.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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