Article
Influence of DNA supercoiling on cisplatin toxicity in Escherichia coli K-12.
Mutation research - 1 Sept 1995
Bouayadi K, Salles B
Abstract excerpt
DNA supercoiling is known to modulate the activity of numerous promoters in vitro and in vivo. Moreover, it has been reported to modulate the rate of formation of cisplatin/DNA crosslinks in vitro. In order to address the question of how the topology influences CDDP toxicity in E. coli, three mutants with altered gyrase activity which led to a decrease of about 25% in superhelical density were studied. Mutant...
Topics
- Adenosine Triphosphatases
- Bacterial Proteins
- Cisplatin
- DNA Adducts
- DNA Repair
- DNA Topoisomerases, Type II
- DNA, Bacterial
- DNA, Superhelical
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Escherichia coli