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Article

Multiple mechanisms of resistance to cisplatin toxicity in an Escherichia coli K12 mutant.

Toxicology - 11 Nov 1994

Salles B, Calsou P, Bouayadi K, Vinial H

Abstract excerpt

The mechanisms underlying cellular resistance to the antitumor drug cis-diamminedichloro-platinum(II) (CDDP) were studied in Escherichia coli K12. A bacterial strain (MC4100/DDP) was selected from the MC4100 wild-type strain after growth for four cycles in CDDP. MC4100/DDP bacteria showed a high level of resistance and exhibited various modifications including (1) a decrease in drug uptake and platinum/DNA...

Topics

Cisplatin
DNA Repair
Drug Resistance
Escherichia coli
Glutathione
Mutation
SOS Response, Genetics
Ultraviolet Rays

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7974517
DOI: 10.1016/0300-483x(94)90081-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7974517-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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