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Article

Expression of the recA gene is reduced in Escherichia coli topoisomerase I mutants.

Mutation research - 1 Apr 1990

Urios A, Herrera G, Aleixandre V, Blanco M

Abstract excerpt

We studied the influence of DNA topological changes on Escherichia coli recA gene expression. This was monitored by measuring beta-galactosidase activity in cells containing a recA-lacZ fusion. To modulate DNA supercoiling we used mutations in the genes encoding for topoisomerase I and DNA gyrase. After either UV irradiation or treatment with the gyrase inhibitor ciprofloxacin, induction of the recA gene was...

Topics

Ciprofloxacin
DNA Topoisomerases, Type I
DNA, Superhelical
Escherichia coli
Gene Expression
Genes, Bacterial
Mutation
Rec A Recombinases
SOS Response, Genetics
Ultraviolet Rays
beta-Galactosidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2157980
DOI: 10.1016/0165-7992(90)90142-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2157980-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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