Article
Effect of DNA topology on plasmid DNA repair in vivo.
FEBS letters - 7 Jul 2000
Park J Y, Ahn B
Abstract excerpt
Escherichia coli nucleotide excision repair (NER) is responsible for removing bulky DNA adducts by dual incisions of the UvrABC endonuclease. Although the activity of the UvrAB complex which can induce DNA conformational change is employed in NER, the involvement of DNA topology and DNA topoisomerases remains unclear. We examined the effect of topoisomerase inhibitions on a NER in vivo system. The repair analysis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.