Article
Resistance to cisplatin in an E. coli B/r NalR mutant.
Mutation research - 1 Jun 1993
Bouayadi K, Villani G, Salles B
Abstract excerpt
The effects of various mutations in DNA-repair processes have been reported to either enhance or decrease bacterial sensitivity to cis-diamminedichloroplatinum(II) (cis-DDP). In the search for other mutations affecting bacterial sensitivity to this antitumor compound, we tested the E. coli B/r BS80 mutant, which is resistant to nalidixic acid (NalR). This mutation maps in the topoisomerase II gene (gyrA subunit)...
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