DNA supercoiling in a thermotolerant mutant of Escherichia coli.

doi:10.1007/BF02191641

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Article

DNA supercoiling in a thermotolerant mutant of Escherichia coli.

Molecular & general genetics : MGG - 30 Aug 1995

Friedman S M, Malik M, Drlica K

Abstract excerpt

A spontaneously occurring, nalidixic acid-resistant (NalR), thermotolerant (T/r) mutant of Escherichia coli was isolated. Bacteriophage P1-mediated transduction showed that NalR mapped at or near gyr A, one of the two genes encoding DNA gyrase. Expression of gyrA+ from a plasmid rendered the muta...

Topics

Chromosome Mapping
DNA Topoisomerases, Type II
DNA, Bacterial
DNA, Superhelical
Escherichia coli
Mutation
Plasmids
Temperature

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