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Article

Identification of Shigella flexneri IcsA residues affecting interaction with N-WASP, and evidence for IcsA-IcsA co-operative interaction.

PloS one - 1 Jan 2013

Teh Min Yan, Morona Renato

Abstract excerpt

The Shigella flexneri IcsA (VirG) protein is a polarly distributed outer membrane protein that is a fundamental virulence factor which interacts with neural Wiskott-Aldrich syndrome protein (N-WASP). The activated N-WASP then activates the Arp2/3 complex which initiates de novo actin nucleation and polymerisation to form F-actin comet tails and allows bacterial cell-to-cell spreading. In a previous study, IcsA...

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Identifiers

PMID: 23405119
DOI: 10.1371/journal.pone.0055152
PMCID: PMC3566212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of Shigella flexneri IcsA residues affecting interaction with N-WASP, and evidence for IcsA-IcsA co-operative interaction.PMID 23405119Read ↗

Absence of O antigen suppresses Shigella flexneri IcsA autochaperone region mutations.Semantic proximity Read ↗

Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility.Semantic proximity Read ↗

Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreadingSemantic proximity Read ↗

Shigella flexneri cell-to-cell spread, and growth and inflammation in mice, is limited by the outer membrane protease IcsP.Semantic proximity Read ↗

Multicopy icsA is able to suppress the virulence defect caused by the wzz(SF) mutation in Shigella flexneri.Semantic proximity Read ↗

Outer membrane protein A (OmpA): a new player in shigella flexneri protrusion formation and inter-cellular spreading.Semantic proximity Read ↗

Actin-based motility is sufficient for bacterial membrane protrusion formation and host cell uptake.Semantic proximity Read ↗

Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility.Semantic proximity Read ↗

Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures.Semantic proximity Read ↗

IcsA surface presentation in Shigella flexneri requires the periplasmic chaperones DegP, Skp, and SurA.Semantic proximity Read ↗

The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function.Semantic proximity Read ↗

Coiled-coil domain of enteropathogenic Escherichia coli type III secreted protein EspD is involved in EspA filament-mediated cell attachment and hemolysis.Semantic proximity Read ↗

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