SepA, the major extracellular protein of Shigella flexneri: autonomous secretion and involvement in tissue invasion.

doi:10.1111/j.1365-2958.1995.mmi_17010123.x

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Article

SepA, the major extracellular protein of Shigella flexneri: autonomous secretion and involvement in tissue invasion.

Molecular microbiology - 1 Jul 1995

Benjelloun-Touimi Z, Sansonetti P J, Parsot C

Abstract excerpt

In addition to Ipa proteins and IcsA, which are involved in entry into epithelial cells and intercellular spread, respectively, Shigella secretes a 110 kDa protein, designated SepA. We report the identification, cloning, and nucleotide sequence determination of the sepA gene, analysis of SepA secretion, and construction and characterization of a sepA mutant. The sepA gene is carried by the virulence plasmid and...

Topics

Amino Acid Sequence
Animals
Bacterial Proteins
Cloning, Molecular
Genes, Bacterial
Ileum
Immunoglobulin A
Molecular Sequence Data
Mucous Membrane
Mutation
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Precursors

Protein Processing, Post-Translational

Rabbits

Sequence Analysis

Sequence Analysis, DNA

Sequence Homology, Amino Acid

Serine Endopeptidases

Source

Open in PubMed

Identifiers

PMID: 7476198
DOI: 10.1111/j.1365-2958.1995.mmi_17010123.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7476198-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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