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Article

The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes.

The Journal of cell biology - 1 Nov 1999

Blocker A, Gounon P, Larquet E, Niebuhr K, Cabiaux V, Parsot C, Sansonetti P

Abstract excerpt

Bacterial type III secretion systems serve to translocate proteins into eukaryotic cells, requiring a secreton and a translocator for proteins to pass the bacterial and host membranes. We used the contact hemolytic activity of Shigella flexneri to investigate its putative translocator. Hemolysis was caused by formation of a 25-A pore within the red blood cell (RBC) membrane. Of the five proteins secreted by...

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Identifiers

PMID: 10545510
DOI: 10.1083/jcb.147.3.683
PMCID: PMC2151192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes.PMID 10545510Read ↗

The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus.Semantic proximity Read ↗

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A translocation-competent pore is required for <i>Shigella flexneri</i> to escape from the double membrane vacuole during intercellular spreadSemantic proximity Read ↗

IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri.Semantic proximity Read ↗

Spa32 regulates a switch in substrate specificity of the type III secreton of Shigella flexneri from needle components to Ipa proteins.Semantic proximity Read ↗

MxiC is secreted by and controls the substrate specificity of the <i>Shigella flexneri</i> type III secretion apparatusSemantic proximity Read ↗

Induction of type III secretion in Shigella flexneri is associated with differential control of transcription of genes encoding secreted proteins.Semantic proximity Read ↗

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