Article
Expression of a constitutive mutant of iron regulatory protein 1 abolishes iron homeostasis in mammalian cells.
The Journal of biological chemistry - 30 Jun 1995
DeRusso P A, Philpott C C, Iwai K, Mostowski H S, Klausner R D, Rouault T A
Abstract excerpt
Iron regulatory proteins (IRPs) are iron-sensing proteins that bind to RNA stem-loop sequences known as iron-responsive elements (IREs) when cells are depleted of iron. Although IRPs have been shown to bind to IREs derived from ferritin and transferrin receptor (TfR) mRNAs in vitro, there has not been a direct demonstration of the impact of a recombinant IRP on the expression of endogenous IRE-containing...
Topics
- Ferritins
- Homeostasis
- Humans
- Iron
- Iron Regulatory Protein 1
- Iron-Regulatory Proteins
- Mutation
- RNA
- RNA-Binding Proteins
- Receptors, Transferrin
- Tumor Cells, Cultured