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Article

Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin.

PLoS genetics - 1 Apr 2013

Sangokoya Carolyn, Doss Jennifer F, Chi Jen-Tsan

Abstract excerpt

Ferroportin (FPN) is the only known cellular iron exporter in mammalian cells and plays a critical role in the maintenance of both cellular and systemic iron balance. During iron deprivation, the translation of FPN is repressed by iron regulatory proteins (IRPs), which bind to the 5' untranslated region (UTR), to reduce iron export and preserve cellular iron. Here, we report a novel iron-responsive mechanism for...

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Identifiers

PMID: 23593016
DOI: 10.1371/journal.pgen.1003408
PMCID: PMC3616902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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