Article
Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin.
PLoS genetics - 1 Apr 2013
Sangokoya Carolyn, Doss Jennifer F, Chi Jen-Tsan
Abstract excerpt
Ferroportin (FPN) is the only known cellular iron exporter in mammalian cells and plays a critical role in the maintenance of both cellular and systemic iron balance. During iron deprivation, the translation of FPN is repressed by iron regulatory proteins (IRPs), which bind to the 5' untranslated region (UTR), to reduce iron export and preserve cellular iron. Here, we report a novel iron-responsive mechanism for...
Topics
- Cation Transport Proteins
- Gene Expression Regulation
- Hep G2 Cells
- Homeostasis
- Humans
- Iron
- Iron-Regulatory Proteins
- K562 Cells
- MicroRNAs
- Mutation
- Protein Binding
- Protein Processing, Post-Translational
- Ferroportin