The physiological functions of iron regulatory proteins in iron homeostasis - an update

doi:10.3389/fphar.2014.00124

Article

The physiological functions of iron regulatory proteins in iron homeostasis - an update

13 Jun 2014

Abstract excerpt

Iron regulatory proteins (IRPs) regulate the expression of genes involved in iron metabolism by binding to RNA stem-loop structures known as iron responsive elements (IREs) in target mRNAs. IRP binding inhibits the translation of mRNAs that contain an IRE in the 5'untranslated region of the transcripts, and increases the stability of mRNAs that contain IREs in the 3'untranslated region of transcripts. By these...

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