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Article

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.

Scientific reports - 23 Mar 2018

Li Huihui, Zhao Hongting, Hao Shuangying, Shang Longcheng, Wu Jing, Song Chuanhui, Meyron-Holtz Esther G, Qiao Tong, Li Kuanyu

Abstract excerpt

Iron is essential for growth and proliferation of mammalian cells. The maintenance of cellular iron homeostasis is regulated by iron regulatory proteins (IRPs) through binding to the cognate iron-responsive elements in target mRNAs and thereby regulating the expression of target genes. Irp1 or Irp2-null mutation is known to reduce the cellular iron level by decreasing transferrin receptor 1 and increasing...

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PMID: 29572489
DOI: 10.1038/s41598-018-23175-y
PMCID: PMC5865113

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ISCU

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