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Article

Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2015

Chen Alan C, Donovan Adriana, Ned-Sykes Renee, Andrews Nancy C

Abstract excerpt

Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin. It is expressed in the intestinal epithelium but not involved in dietary iron absorption. To investigate its role, we inactivated the Tfr1 gene selectively in murine intestinal epithelial cells. The mutant mice had severe disruption of the epithelial barrier and early death. There was...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26324903
DOI: 10.1073/pnas.1511701112
PMCID: PMC4577163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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