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Article

Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway.

Molecular and cellular biology - 1 Apr 2007

Wang Jian, Fillebeen Carine, Chen Guohua, Biederbick Annette, Lill Roland, Pantopoulos Kostas

Abstract excerpt

Iron regulatory protein 1 (IRP1) controls the translation or stability of several mRNAs by binding to "iron-responsive elements" within their untranslated regions. In iron-replete cells, IRP1 assembles a cubane iron-sulfur cluster (ISC) that inhibits RNA-binding activity and converts the protein to cytosolic aconitase. We show that the constitutive IRP1(C437S) mutant, which fails to form an ISC, is destabilized...

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Identifiers

PMID: 17242182
DOI: 10.1128/MCB.01111-06
PMCID: PMC1899896

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Source receipt: pubmed, retrieved 7 Sept 2026.

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