Article
Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.
Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 1995
Shirasaka T, Kavlick M F, Ueno T, Gao W Y, Kojima E, Alcaide M L, Chokekijchai S, Roy B M, Arnold E, Yarchoan R
Abstract excerpt
A set of mutations [Ala-62-->Val(A62V), V75I, F77L, F116Y, and Q151M] in the polymerase domain of reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) confers on the virus a reduced sensitivity to multiple antiretroviral dideoxynucleosides and has been seen in HIV-1 variants...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA Primers
- Dideoxynucleosides
- Dose-Response Relationship, Drug
- Drug Resistance, Multiple
- Genes, pol
- Genetic Variation