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Article

Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 1995

Shirasaka T, Kavlick M F, Ueno T, Gao W Y, Kojima E, Alcaide M L, Chokekijchai S, Roy B M, Arnold E, Yarchoan R

Abstract excerpt

A set of mutations [Ala-62-->Val(A62V), V75I, F77L, F116Y, and Q151M] in the polymerase domain of reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) confers on the virus a reduced sensitivity to multiple antiretroviral dideoxynucleosides and has been seen in HIV-1 variants isolated from patients receiving combination chemotherapy with 3'-azido-3'-deoxythymidine (AZT) plus...

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Identifiers

PMID: 7534421
DOI: 10.1073/pnas.92.6.2398
PMCID: PMC42491

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Source receipt: pubmed, retrieved 7 Sept 2026.

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