Article
Development and significance of nucleoside drug resistance in infection caused by the human immunodeficiency virus type 1.
Clinical and investigative medicine. Medecine clinique et experimentale - 1 Jun 1994
Smith M, Salomon H, Wainberg M A
Abstract excerpt
Nucleoside antagonists of human immunodeficiency virus (HIV) reverse transcriptase (RT) activity have been commonly used in the therapy of HIV-associated disease. The prolonged use of such drugs has led to the development of HIV variants that display resistance against these compounds. HIV drug resistance has been documented clinically for each of the following nucleosides: 3'-azido-3'-deoxythymidine (AZT;...
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