Article
A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance.
Antimicrobial agents and chemotherapy - 1 Aug 1999
Larder B A, Bloor S, Kemp S D, Hertogs K, Desmet R L, Miller V, Sturmer M, Staszewski S, Ren J, Stammers D K, Stuart D I, Pauwels R
Abstract excerpt
To investigate the occurrence of multinucleoside analog resistance during therapy failure, we surveyed the drug susceptibilities and genotypes of nearly 900 human immunodeficiency virus type 1 (HIV-1) samples. For 302 of these, the 50% inhibitory concentrations of at least four of the approved nucleoside analogs had fourfold-or-greater increases. Genotypic analysis of the reverse transcriptase (RT)-coding regions...
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