Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance.

doi:10.1086/515282

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Article

Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance.

The Journal of infectious diseases - 1 May 1998

Maeda Y, Venzon D J, Mitsuya H

Abstract excerpt

Investigations were done to determine whether the replication kinetics of human immunodeficiency virus (HIV)-1 were altered when the virus acquired a set or subsets of five mutations (A62V, V75I, F77L, F116Y, and Q151M) in the pol gene conferring resistance to multiple dideoxynucleosides. In the...

Topics

Animals
Anti-HIV Agents
COS Cells
Cells, Cultured
Didanosine
Dideoxynucleosides
Drug Resistance, Microbial
Drug Resistance, Multiple
Evolution, Molecular
Genes, pol
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes

Microbial Sensitivity Tests

Mutation

Virus Replication

Zalcitabine

Zidovudine

Source

Open in PubMed

Identifiers

PMID: 9593005
DOI: 10.1086/515282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9593005-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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