Article
Pathways for the emergence of multi-dideoxynucleoside-resistant HIV-1 variants.
AIDS (London, England) - 23 May 2003
Matsumi Shintaro, Kosalaraksa Pope, Tsang Hsinyi, Kavlick Mark F, Harada Shigeyoshi, Mitsuya Hiroaki
Abstract excerpt
OBJECTIVE: To investigate the mechanism by which the Q151M mutation in reverse transcriptase (RT) that confers multi-dideoxynucleoside resistance on HIV-1 and that requires a two base change (CAG-->ATG) develops, and to understand the reason for the relatively lengthy period of time required for its emergence under therapy with multiple nucleoside RT inhibitors (NRTI). DESIGN AND METHODS: Propagation assays and...
Topics
- Anti-HIV Agents
- Didanosine
- Dideoxynucleosides
- Drug Resistance, Multiple, Viral
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Mutation
- Reverse Transcriptase Inhibitors
- Virus Replication
- Zidovudine