Article
Novel mutation (V75T) in human immunodeficiency virus type 1 reverse transcriptase confers resistance to 2',3'-didehydro-2',3'-dideoxythymidine in cell culture.
Antimicrobial agents and chemotherapy - 1 Jun 1994
Lacey S F, Larder B A
Abstract excerpt
We have selected a human immunodeficiency virus type 1 (HIV-1) mutant strain with a moderate (sevenfold) level of resistance to the nucleoside analog 2',3'-didehydro-2',3'-dideoxythymidine (D4T or stavudine). After serial passage of the HXB2 strain of HIV-1 in MT4 cells, a novel mutation involvin...
Topics
- Base Sequence
- Cells, Cultured
- Drug Resistance, Microbial
- Emtricitabine
- HIV Reverse Transcriptase
- HIV-1
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- RNA-Directed DNA Polymerase
- Reverse Transcriptase Inhibitors
- Stavudine
- Zalcitabine
- Zidovudine