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Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs.

Nucleic acids research - 1 Jan 2012

Herman Brian D, Schinazi Raymond F, Zhang Hong-wang, Nettles James H, Stanton Richard, Detorio Mervi, Obikhod Aleksandr, Pradère Ugo, Coats Steven J, Mellors John W, Sluis-Cremer Nicolas

Abstract excerpt

β-D-3'-Azido-2',3'-dideoxyguanosine (3'-azido-ddG) is a potent inhibitor of HIV-1 replication with a superior resistance profile to zidovudine. Recently, we identified five novel 6-modified-3'-azido-ddG analogs that exhibit similar or superior anti-HIV-1 activity compared to 3'-azido-ddG in primary cells. To gain insight into their structure-activity-resistance relationships, we synthesized their triphosphate...

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Identifiers

PMID: 21914723
DOI: 10.1093/nar/gkr756
PMCID: PMC3245946

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Source receipt: pubmed, retrieved 7 Sept 2026.

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