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Article

Identification of novel mutations that confer drug resistance in the human immunodeficiency virus polymerase gene.

Leukemia - 1 Apr 1994

Gu Z, Gao Q, Fang H, Parniak M A, Brenner B G, Wainberg M A

Abstract excerpt

We generated variants of the human immunodeficiency virus type 1 (HIV-1) that are resistant to 2',3'-dideoxycytidine (ddC) and 2',3'-didehydro-3'-deoxythymidine (d4T) by in vitro selection in MT-4 cells. Portions of flanking protease and integrase sequences as well as the complete reverse transcriptase (RT) open-reading frame of these viruses were cloned and sequenced, using polymerase chain reaction (PCR)-based...

Topics

Drug Resistance
HIV Reverse Transcriptase
HIV-1
Humans
Mutation
RNA-Directed DNA Polymerase
Zidovudine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7512178

Genes

AGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7512178-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Identification of novel mutations that confer drug resistance in the human immunodeficiency virus polymerase gene.PMID 7512178Read ↗

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