Article
Emergence of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 variants, viral sequence variation, and disease progression in patients receiving antiretroviral chemotherapy.
The Journal of infectious diseases - 1 Jun 1998
Kavlick M F, Wyvill K, Yarchoan R, Mitsuya H
Abstract excerpt
A set of five reverse transcriptase mutations, which include Q151M, is known to confer multi-dideoxynucleoside resistance (MDR) in human immunodeficiency virus type 1 (HIV-1). MDR mutations were found in 6 (17%) HIV-1 isolates from 36 patients, most of whom were receiving long-term combination th...
Topics
- Adult
- Anti-HIV Agents
- CD4 Lymphocyte Count
- Child
- Didanosine
- Dideoxynucleosides
- Disease Progression
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- Drug Therapy, Combination
- Genetic Variation
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Point Mutation
- RNA, Viral
- Reverse Transcriptase Inhibitors