Article
pol mutations conferring zidovudine and didanosine resistance with different effects in vitro yield multiply resistant human immunodeficiency virus type 1 isolates in vivo.
Antimicrobial agents and chemotherapy - 1 Jul 1993
Eron J J, Chow Y K, Caliendo A M, Videler J, Devore K M, Cooley T P, Liebman H A, Kaplan J C, Hirsch M S, D'Aquila R T
Abstract excerpt
Specific mutations in the human immunodeficiency virus type 1 (HIV-1) pol gene that cause zidovudine (3'-azido-2',3'-dideoxythymidine; AZT) and didanosine (2',3'-dideoxyinosine; ddI) resistance were studied. The 50% inhibitory concentrations (IC50s) of nucleosides for cloned viruses containing these mutations were compared with the IC50s of the corresponding triphosphate analogs for mutant recombinant-expressed...
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