Article
An analysis of fetal hemoglobin variation in sickle cell disease: the relative contributions of the X-linked factor, beta-globin haplotypes, alpha-globin gene number, gender, and age.
Blood - 15 Feb 1995
Chang Y C, Smith K D, Moore R D, Serjeant G R, Dover G J
Abstract excerpt
Five factors have been shown to influence the 20-fold variation of fetal hemoglobin (Hb F) levels in sickle cell anemia (SS): age, sex, the alpha-globin gene number, beta-globin haplotypes, and an X-linked locus that regulates the production of Hb F-containing erythrocytes (F cells), ie, the F-cell production (FCP) locus. To determine the relative importance of these factors, we studied 257 Jamaican SS subjects...
Topics
- Adolescent
- Adult
- Analysis of Variance
- Anemia, Sickle Cell
- Child
- Chromosome Mapping
- Cohort Studies
- Erythrocytes
- Female
- Fetal Hemoglobin
- Genetic Variation