Genetic Polymorphisms Associated with Fetal Hemoglobin (HbF) Levels and F-Cell Numbers: A Systematic Review of Genome-Wide Association Studies.

doi:10.3390/ijms252111408

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Article

Genetic Polymorphisms Associated with Fetal Hemoglobin (HbF) Levels and F-Cell Numbers: A Systematic Review of Genome-Wide Association Studies.

International journal of molecular sciences - 23 Oct 2024

Stephanou Coralea, Menzel Stephan, Philipsen Sjaak, Kountouris Petros

Abstract excerpt

Elevated fetal hemoglobin (HbF), which is partly controlled by genetic modifiers, ameliorates disease severity in β hemoglobinopathies. Understanding the genetic basis of this trait holds great promise for personalized therapeutic approaches. PubMed, MedRxiv, and the GWAS Catalog were searched up to May 2024 to identify eligible GWAS studies following PRISMA guidelines. Four independent reviewers screened,...

Topics

Humans
Fetal Hemoglobin
Genome-Wide Association Study
Polymorphism, Single Nucleotide

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Identifiers

PMID: 39518961
DOI: 10.3390/ijms252111408
PMCID: PMC11546522

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