Article
BCL11A and HBS1L-MYB polymorphisms, in association with hydroxyurea and sex, modulate fetal hemoglobin levels in individuals with sickle cell anemia in the western region of Bahia, Brazil.
Molecular biology reports - 23 Jun 2026
de Magalhães Filho Manoel Ferreira, Santana Ilana Luize Rocha, da Silva Pâmela Lourdes Pereira, Venancio Larissa Paola Rodrigues
Abstract excerpt
BACKGROUND: Sickle cell anemia (SCA) is a condition caused by a mutation in the HBB gene, leading to the production of hemoglobin S in red blood cells. Hydroxyurea (HU), used in treatment, increases fetal hemoglobin (HbF) levels, thereby reducing erythrocyte sickling, as do single-nucleotide polymorphisms (SNPs) in the BCL11A gene and the HBS1L-MYB intergenic region. In this study, we investigated the combined...
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