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Article

Fetal Hemoglobin Modulation in Sickle Cell Disease: βs Haplotypes, Key Polymorphisms Identified by GWAS, and Advances in γ-Globin Editing: An Updated Overview.

Genes - 27 Jan 2026

Márquez-Benitez Yusselfy, Osorio-Garzón Valeria Isabela, Bernal-Villegas Jaime Eduardo, Briceño-Balcázar Ignacio

Abstract excerpt

Fetal hemoglobin (HbF) plays a central role in mitigating the pathophysiological effects of sickle cell disease (SCD). Understanding the genetic determinants influencing HbF expression is essential for identifying the factors contributing to its modulation. This review provides an updated synthesis of evidence on HbF modulation, focusing on βs haplotypes and their molecular characterization through Sanger...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41751519
DOI: 10.3390/genes17020135
PMCID: PMC12941278

Genes

SCD
BACH2
BCL11A
HBB
HBS1L
KLF1
MYB
NFIX
ZBTB7A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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