Article
The relative importance of the X-linked FCP locus and beta-globin haplotypes in determining haemoglobin F levels: a study of SS patients homozygous for beta S haplotypes.
British journal of haematology - 1 Mar 1997
Chang Y P, Maier-Redelsperger M, Smith K D, Contu L, Ducroco R, de Montalembert M, Belloy M, Elion J, Dover G J, Girot R
Abstract excerpt
Five factors have been hypothesized to influence the 20-fold variation in fetal haemoglobin (Hb F) levels in sickle cell anaemia (SS): age sex, alpha-globin gene number, beta-globin haplotype, and the X-linked F-cell production locus (FCP) that regulates the production of Hb F containing erythrocytes (F cells). We analysed the association of these factors with Hb F levels in 112 SS patients living in France who...
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