Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2.

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Article

Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2.

Blood - 1 Aug 1992

Dover G J, Smith K D, Chang Y C, Purvis S, Mays A, Meyers D A, Sheils C, Serjeant G

Abstract excerpt

Fetal hemoglobin (Hb F) production in sickle cell (SS) disease and in normal individuals varies over a 20-fold range and is under genetic control. Previous studies suggested that variant Hb F levels might be controlled by genetic loci separate from the beta-globin complex on chromosome 11. Using...

Topics

Adult
Anemia, Sickle Cell
Child
Chromosome Banding
Chromosome Mapping
Cohort Studies
Female
Fetal Hemoglobin
Globins
Humans
Male
Pedigree
Phenotype
Polymorphism, Restriction Fragment Length
Reference Values
Sex Characteristics
X Chromosome

Source

Open in PubMed

Identifiers

PMID: 1379090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1379090-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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